AB082. Effect of cryopreservation on DNA methylation status of imprinted genes in human sperm
نویسندگان
چکیده
© Translational Andrology and Urology. All rights reserved. Transl Androl Urol, 2015;4(S1) www.amepc.org/tau observed. 3.9% (8/204) of the patients complained that the orgasms were slightly decreased in orgasmic intensity after operation, but 96.1% (196/204) of the patients did not complain any change of the orgasms. Conclusions: The transurethral seminal vesiculoscopy examination and related procedure including dilation of ejaculatory ducts, incision of the verumontanum or the distal end of the ejaculatory ducts, and incision or resection of the relevant cysts represent a kind of simple, effective, safe and reliable approaches for the management of refractory cases of hematospermia that do not respond to conservative treatments.
منابع مشابه
P-31: Effect of Cryptop Vitrification on DNAMethylation Pattern of Oct4 and Mest Genes inMurine Preimplantation Embryos
Background: Because of the protection of surplus embryos, Cryopreservation is usually used in ART. It is not clear, the vitrified-warmed embryos that have normal morphology, be normal in genetic level, too. DNA methylation of gene regulatory regions can causes inhibition of gene expression. We study effect of vitrification method of cryopreservation on DNA methylation and gene expression level ...
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Background Genomic imprinting is a heritable and developmentally essential phenomenon by which gene expression occurs in an allele-specific manner1. While the imprinted alleles are primarily silenced by DNA methylation, it remains largely unknown how methylation is targeted to imprinting control region (ICR), also called differentially methylated region (DMR), and maintained. Here we show that ...
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s:1993:"Background: There are many approaches that gene expression is controlled in eukaryotes. DNA methylation is one of several epigenetic mechanisms that cells use to control gene expression and lock genes in the "off" position. In addition, sperm DNA damage can correlate with DNA methylation defect. There is evidence that sperm of infertile men contain more DNA damage than fertile men and t...
متن کاملEpigenetic germline mosaicism in infertile men.
Imprinted genes are expressed either from the paternal or the maternal allele, because the other allele has been silenced in the mother's or father's germline. Imprints are characterized by DNA methylation at cytosine phosphate guanine sites. Recently, abnormal sperm parameters and male infertility have been linked to aberrant methylation patterns of imprinted genes in sperm DNA. However, these...
متن کاملNerve growth factor in human semen: Effect of nerve growth factor on the normozoospermic men during cryopreservation process
Objective(s):Althoughroutinely applied in assisted reproductive technology, human sperm cryopreservation is not a completely successful procedure. Adverse effects of cryopreservation on the fertilization capacity, motility, morphology, and viability of spermatozoa have been proven; cryopreservation has also shown a role in sperm DNA fragmentation and infertility. The post-thaw survival of sperm...
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